Conventional / global / constitutive KO
●2 Models Available
Tlr9 Conditional Knockout, Knockout mouse models
Browse 2 Tlr9 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Tlr9 conditional knockout mouse, Tlr9 knockout mouse. Contact us for availability and fast turnaround.
Why model Tlr9
Recognition of microbial DNA runs through Tlr9, the mouse ortholog of human TLR9, whose endosomal receptor binds unmethylated CpG-containing single-stranded DNA at a site on the concave ectodomain surface while a second pocket engages a free 5 prime xCx dinucleotide, cooperativity that explains why activation is sequence and end dependent and why UNC93B1 trafficking plus cathepsin-mediated cleavage are prerequisites for signaling to MyD88, IRAK4, and IRF7. Species divergence is practical rather than theoretical, since mouse TLR9 prefers GACGTT-containing motifs whereas human TLR9 favors GTCGTT, so CpG oligonucleotide adjuvants and antagonists are not interchangeable and ectodomain humanization is warranted for translational pharmacology. Nulls are viable and, importantly, show worsened lupus in several autoimmune backgrounds despite reduced anti-DNA responses, revealing a regulatory function that complicates simple loss of function logic. Because Tlr7 shares the UNC93B1 and IRF7 axis, plan compound alleles around interferon output, autoantibody specificity, or adjuvant potency.
What Tlr9 mouse models are available?
ingenious targeting laboratory offers 2 distinct Tlr9 (TLR9) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Tlr9 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Tlr9 allele types
Knockout, conditional, knockin, humanized, and related paths for Tlr9 (human TLR9). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Tlr9 catalog models
2 Tlr9 lines with QC documentation and technical support. Tlr9 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Selected publications from ingenious targeting laboratory
Peer reviewed work involving Tlr9 (TLR9) from ITL supported projects.
- B cell-intrinsic TLR9 expression is protective in murine lupusTilstra JS, John S, Gordon RA, Leibler C, Kashgarian M, Bastacky S, Nickerson KM, Shlomchik MJ. (2020). J Clin Invest 130(6): 3172-3187
Looking for a Tlr9 mouse model?
We have 2 Tlr9 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Tlr9 Mouse Model Types
A Tlr9 knockout mouse has the Tlr9 gene permanently inactivated, enabling loss of function studies. A Tlr9 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Tlr9, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Tlr9 organized by modification type. Each URL is indexable and matches common search patterns.