Conventional / global / constitutive KO
●3 Models Available
Tlr4 Conditional Knockout, Knockout mouse models
Browse 3 Tlr4 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Tlr4 conditional knockout mouse, Tlr4 knockout mouse. Request a quote within 24 hours.
Why model Tlr4
Tlr4 is the mouse ortholog of human TLR4 and encodes the lipopolysaccharide receptor, which requires the accessory protein MD-2 (Ly96) to form a pocket accommodating five of the six lipid A acyl chains while CD14 and LBP deliver ligand, and dimerization then triggers MyD88 and TIRAP signaling at the plasma membrane followed by TRAM and TRIF dependent IRF3 activation after endocytosis. Species specificity is a first-order design issue, since mouse and human MD-2 and TLR4 differ in their response to underacylated lipid A species, so lipid A mimetics, monophosphoryl lipid A adjuvants, and antagonists such as eritoran behave differently, which is why humanized Tlr4 and Ly96 knockins are used for adjuvant and sepsis pharmacology. The spontaneous P712H allele and complete nulls are both viable, so conditional deletion in myeloid, endothelial, or intestinal epithelial compartments is the refinement step, with endotoxin shock, neuropathic pain, or steatohepatitis endpoints dictating allele choice.
What Tlr4 mouse models are available?
ingenious targeting laboratory offers 3 distinct Tlr4 (TLR4) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Tlr4 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Tlr4 allele types
Knockout, conditional, knockin, humanized, and related paths for Tlr4 (human TLR4). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Tlr4 catalog models
3 Tlr4 lines with QC documentation and technical support. Tlr4 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Selected publications from ingenious targeting laboratory
Peer reviewed work involving Tlr4 (TLR4) from ITL supported projects.
- A Mouse Model for the Study of SYK Function through Chemical Genetics Demonstrates SYK-Dependent Signaling through the B Cell Receptor, but Not TLR4Wang WH, Krisenko MO, Higgins RL, Morman RE, Geahlen RL. (2019). Immunohorizons 3(7): 254-261
- Group X secretory phospholipase A2 enhances TLR4 signaling in macrophages.Shridas P, Bailey WM, Talbott KR, Oslund RC, Gelb MH, Webb NR. (2011). J Immunol187: 482-489
Looking for a Tlr4 mouse model?
We have 3 Tlr4 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Tlr4 Mouse Model Types
A Tlr4 knockout mouse has the Tlr4 gene permanently inactivated, enabling loss of function studies. A Tlr4 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Tlr4, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Tlr4 organized by modification type. Each URL is indexable and matches common search patterns.