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Found 9 models matching “C57BL/6”
| Gene | Model | Type | Category | Status | Catalog | |
|---|---|---|---|---|---|---|
| C57BL/6 | C57BL/6 | Other | LIVE | SM 001 | Inquire | |
| It was the first mouse strain to have its genome sequenced. With black coat color, it is recognized as the "standard" inbred strain and provides genetic background for numerous mutant genes. It is characterized by stable strain properties, ease of breeding, uniform stress responses, and high precision in experimental results. | ||||||
| CAG | CAG-LSL-dCas9-SPH-Tg | TG | LIVE | TG 00025 | Inquire | |
| Cre-dependent SunTag-p65-HSF1 (SPH) transgenic mice were generated with piggyBac transposon system in F1 zygotes and crossed with wild type C57BL/6 mice., SPH transgenic mouse containing HA-tagged dCas9 fused with 10xGCN4, which is linked with p65-HSF1 and EGFP in tandem via P2A and T2A respectively. The transgene is driven by the ubiquitous CAG promoter and interrupted by a loxP-stop-loxP (LSL) cassette to render Cas9 expression inducible by the Cre recombinase. Expression of dCas9 can be detected using primary antibody: rabbit monoclonal antibody to HA-tag (1:1000, #3724, CST45) and secondary antibody: goat anti-rabbit Alexa Fluor 488 (1:1000, #A-11034, Thermo Fisher). *This strain is a client-donated line. The donor's publication indicates that fluorescence was observed by immunofluorescence. The JAX description of this strain also explicitly states that fluorescence cannot be directly observed. | ||||||
| Apc | Apc-L850X | KI | LIVE | KI 200001 | Inquire | |
| Familial adenomatous polyposis (FAP) is a heritable condition in which affected individuals develop benign intestinal polyps. Often, polyps progress to colorectal carcinomas later in life. The mutation of C57BL/6-Apcem1(L850X)iTL(KI 200001) strain of iTL refers to the ApcMin model (Jax: 002020 ), a useful model to study intestinal adenomas. The C57BL/6-Apcem1(L850X)iTL strain is highly susceptible to spontaneous intestinal adenoma formation and can be used as a research model for human FAP. These mice carry a p.L850X mutation of Apc gene. | ||||||
| Hbb | Hbb-bs-Flox/Prrx1-2A-CreERT2(C57BL/6Smoc) | XA | LIVE | XA 261354 | Inquire | |
| The Hbb-bs-Flox (CKO 241573) was crossed with Prrx1-2A-CreERT2(KI 225017) to generate Hbb-bs-Flox/Prrx1-2A-CreERT2 mice. | ||||||
| MHC Class II (I | MHC Class II (I-A/I-E) -KO | KO | LIVE | KO 18032 | Inquire | |
| All sequences from the upstream of mouse H2-Ab1 gene exon 2 to the upstream of the H2-Ea-ps gene exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models. These MHC class II molecule-deficient mice were on the C57BL/6J genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins. | ||||||
| Ndrg2 | Ndrg2-Flox/Vil1-CreERT2(C57BL/6Smoc) | XA | DEVELOPING | XA 261407 | Inquire | |
| The Ndrg2-Flox (CKO 234582) was crossed with Vil1-CreERT2(KI 225020) to generate Ndrg2-Flox/Vil1-CreERT2 mice. | ||||||
| Nnt | Nnt-Flox(C57BL/6N) | CKO | SPERM | CKO 241631 | Inquire | |
| These strains carry loxP sites flanking exon 6 of Nnt gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Nnt gene. | ||||||
| Nnt | Nnt-KO(C57BL/6NSmoc) | KO | SPERM | KO 251159 | Inquire | |
| The exon 6 of Nnt gene was deleted to generate Nnt knockout mouse. | ||||||
| Sdhb | Sdhb-Flox/Pgr-IRES-Cre(C57BL/6Smoc) | XA | LIVE | XA 261365 | Inquire | |
| The Sdhb-Flox (CKO 226004) was crossed with Pgr-IRES-Cre(KI 200150) to generate Sdhb-Flox/Pgr-IRES-Cre mice. | ||||||
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