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Search our extensive catalog of over 14,774 genetically engineered mouse models including knockout, knockin, humanized, Cre driver, and reporter strains for biomedical research and drug development.
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Explore 14,774+ genetically engineered mouse and rat models
Found 25+ models matching “disease”
| Gene | Model | Type | Category | Status | Catalog | |
|---|---|---|---|---|---|---|
| Cdkn2D | Cdkn2D-KO/Jak2-Flox-V617F/Vav1-2A-Cre | XA | DEVELOPING | XA 263271 | Inquire | |
| The Cdkn2D-KO (KO 2107647) was crossed with Jak2-Flox-V617F/Vav1-2A-Cre(XA 260618) to generate Cdkn2D-KO/Jak2-Flox-V617F/Vav1-2A-Cre mice. | ||||||
| huPBMC | huPBMC-(MHCII/B2M-KO M-NSG) | HU | LIVE | HU 263012 | Inquire | |
| MHCII and B2m genes were knocked out on NMG mice. An immune reconstitution model was constructed by transplanting fresh human peripheral blood mononuclear cells (PBMCs) into MHCII/B2M-KO(NMG) mice. This model exhibits a low degree of graft-versus-host disease (GvHD). | ||||||
| Ptf1a | Ptf1a-CreERT2/Kras-LSL-G12D | XA | DEVELOPING | XA 262922 | Inquire | |
| The Ptf1a-CreERT2 (KI 200118) was crossed with Kras-LSL-G12D(KI 190003) to generate Ptf1a-CreERT2/Kras-LSL-G12D mice. | ||||||
| Jade1 | Jade1-Flox/Cx3cr1-Cre | XA | DEVELOPING | XA 262058 | Inquire | |
| The Jade1-Flox (CKO 253022) was crossed with Cx3cr1-Cre(KI 200079) to generate Jade1-Flox/Cx3cr1-Cre mice. | ||||||
| Trpm7 | Trpm7-Flox/Itga8-CreERT2 | XA | DEVELOPING | XA 261653 | Inquire | |
| The Trpm7-Flox (CKO 226337) was crossed with Itga8-CreERT2(KI 260076) to generate Trpm7-Flox/Itga8-CreERT2 mice. | ||||||
| Hbb | Hbb-bs-Flox/Prrx1-2A-CreERT2(C57BL/6Smoc) | XA | LIVE | XA 261354 | Inquire | |
| The Hbb-bs-Flox (CKO 241573) was crossed with Prrx1-2A-CreERT2(KI 225017) to generate Hbb-bs-Flox/Prrx1-2A-CreERT2 mice. | ||||||
| R26 | R26-CAG-LSL-Nrg1/Alb-CreERT2(B6;129S) | XA | DEVELOPING | XA 260949 | Inquire | |
| The R26-CAG-LSL-Nrg1 (KI 250689) was crossed with Alb-CreERT2(KI 00002) to generate R26-CAG-LSL-Nrg1/Alb-CreERT2 mice. | ||||||
| Jak2 | Jak2-Flox-V617F/Vav1-2A-Cre | XA | DEVELOPING | XA 260618 | Inquire | |
| The Jak2-Flox-V617F (KI 210367) was crossed with Vav1-2A-Cre(KI 233228) to generate Jak2-Flox-V617F/Vav1-2A-Cre mice. | ||||||
| Ncoa6 | Ncoa6-Flox | CKO | IN PRODUCTION | CKO 253931 | Inquire | |
| These mice carry loxP sites flanking exon 10 of Ncoa6 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Ncoa6 gene. | ||||||
| Daam1 | Daam1-Flox | CKO | IN PRODUCTION | CKO 253930 | Inquire | |
| These mice carry loxP sites flanking exon 6 of Daam1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Daam1 gene. | ||||||
| Mdm4 | Mdm4-Flox | CKO | LIVE | CKO 253927 | Inquire | |
| These mice carry loxP sites flanking exon 3-5 of Mdm4 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Mdm4 gene. | ||||||
| Esrrb | Esrrb-Flox | CKO | IN PRODUCTION | CKO 253925 | Inquire | |
| These mice carry loxP sites flanking exon 2 of Esrrb gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Esrrb gene. | ||||||
| Yme1l1 | Yme1l1-Flox | CKO | LIVE | CKO 253857 | Inquire | |
| These mice carry loxP sites flanking exon 3 of Yme1l1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Yme1l1 gene. | ||||||
| Psen2 | Psen2-Flox | CKO | IN PRODUCTION | CKO 253856 | Inquire | |
| These mice carry loxP sites flanking exon 3 of Psen2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Psen2 gene. | ||||||
| Madd | Madd-Flox | CKO | IN PRODUCTION | CKO 253854 | Inquire | |
| These mice carry loxP sites flanking exon 3-4 of Madd gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Madd gene. | ||||||
| Gadd45gip1 | Gadd45gip1-Flox | CKO | IN PRODUCTION | CKO 253850 | Inquire | |
| These mice carry loxP sites flanking exon 1 of Gadd45gip1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Gadd45gip1 gene. | ||||||
| B6 DIO | B6 DIO | Other | LIVE | SM 021 | Inquire | |
| Diet-induced obesity (DIO) models are similar to human obesity, can effectively reflect the pathogenesis of human obesity, and are useful for studying metabolic diseases such as obesity, diabetes, and fatty liver disease. | ||||||
| Dot1l | Dot1l-Flox | CKO | IN PRODUCTION | CKO 253748 | Inquire | |
| These mice carry loxP sites flanking exon 2 of Dot1l gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Dot1l gene. | ||||||
| Sidt2 | Sidt2-KO | KO | SPERM | KO 253522 | Inquire | |
| The exon 7-8 of Sidt2 gene was deleted to generate Sidt2 knockout mouse. | ||||||
| Brinp1 | Brinp1-KO | KO | SPERM | KO 201132 | Inquire | |
| Exon 3 of Brinp1 gene was deleted to generate Brinp1 knockout mice. | ||||||
| hFCRN(M | hFCRN(M-NSG) | NSG | LIVE | NSG 020 | Inquire | |
| The background of this strain is NMG, and its endogenous Fcgrt gene is replaced with human FCGRT. | ||||||
| Agxt | Agxt-KO | KO | EMBRYO | KO 210152 | Inquire | |
| Exon 3-8 of Agxt gene was deleted to generate Agxt knockout mice. | ||||||
| Glp1r | Glp1r-KO | KO | LIVE | KO 190803 | Inquire | |
| Exon 2 of Glp1r gene was deleted to generate Glp1r knockout mice. | ||||||
| Abcd1 | Abcd1-KO | KO | SPERM | KO 2106014 | Inquire | |
| Exon 2 of Abcd1 gene was deleted to generate Abcd1 knockout mice. | ||||||
| Idh1 | Idh1-KO | KO | SPERM | KO 2110552 | Inquire | |
| Exon 3 of Idh1 gene was deleted to generate Idh1 knockout mice. | ||||||
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