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Found 7 models matching “floxed”
| Gene | Model | Type | Category | Status | Catalog | |
|---|---|---|---|---|---|---|
| Spred1 | Spred1-Flox | CKO | SPERM | CKO 200299 | Inquire | |
| This product was constructed with reference to the literature (PubMed ID: 21668589), in which loxP sites were inserted on both sides of exon 7 in the Spred1 gene transcript ENSMUST00000028829. The floxed region does not encompass the complete transcript ENSMUST00000110901. | ||||||
| Slco1c1 | Slco1c1-2A-CreERT2 | KI | LIVE | KI 200262 | Inquire | |
| 2A-CreERT2 expression cassette was knocked into the Slco1c1 gene stop codon site. Slco1c1 encodes a member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. When Slco1c1-2A-CreERT2 mice are bred with mice containing loxP-flanked sequence, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in SLCO1C1 positive cells. | ||||||
| Notch1 | Notch1-CreERT2 | KI | SPERM | KI 200122 | Inquire | |
| A CreERT2-2xpA expression cassette was knocked into the Notch1 gene start codon site. Notch1 performs vital cell functions, such as proliferation, differentiation, apoptosis, and stem cell maintenance. When Notch1-CreERT2 mice are bred with mice containing loxP-flanked sequence, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in NOTCH1 positive cells. | ||||||
| Slc6a11 | Slc6a11-CreERT2 | KI | SPERM | KI 200130 | Inquire | |
| A CreERT2-polyA expression cassette was knocked into the Slc6a11 gene start codon site. Slc6a11 encodes GAT3 (Gabt4), a sodium-dependent transporter that uptakes the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), which ends the GABA neurotransmission. When Slc6a11-CreERT2 mice are bred with mice containing loxP-flanked sequence, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in SLC6A11positive cells. Defects in Slc6a11 may result in epilepsy or behavioral and intellectual defects. | ||||||
| Prox1 | Prox1-IRES-CreERT2 | KI | LIVE | KI 200119 | Inquire | |
| A IRES-CreERT2-pA expression cassette was knocked into the Prox1 gene stop codon site. Prox1 encodes a transcription factor (prospero-related homeobox 1) that is necessary for the formation and maintenance of lymphatic vessels. When Prox1-IRES-CreERT2 mice are bred with mice containing loxP-flanked sequence, tamoxifen-inducible Cre-mediated recombination will result in deletion of the floxed sequences in PROX1positive cells. | ||||||
| Cth | Cth-Luc | KI | EMBRYO | KI 00004 | Inquire | |
| Cth was targeted by insertion of a floxed Luciferase gene and an frt-neo-frt cassette before exon 1. These mice have normal development and fertility. | ||||||
| hCD24 | hCD24-Flox | HU | EMBRYO | HU 231034 | Inquire | |
| The endogenous mouse Cd24a exon2 was replaced by floxed humanized CD24 exon2. | ||||||
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