Conventional / global / constitutive KO
●3 Models Available
Cox10 Conditional Knockout, Knockout mouse models
Browse 3 Cox10 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Cox10 conditional knockout mouse, Cox10 knockout mouse. Contact us for availability and fast turnaround.
Why model Cox10
Heme A biosynthesis begins with Cox10, the mouse ortholog of human COX10, which encodes the inner membrane heme A farnesyltransferase that converts protoheme, or heme B, into heme O by farnesylating a vinyl side chain, the committed first step toward the heme A cofactors of cytochrome c oxidase. Without heme A, subunit MT-CO1 cannot mature, so complex IV assembly stalls and the enzyme is degraded, producing isolated cytochrome c oxidase deficiency. Human COX10 mutations cause Leigh syndrome, leukodystrophy with tubulopathy, and fatal infantile encephalomyopathy, and conditional mouse alleles have been used productively to generate muscle and neuron restricted complex IV deficiency. Design accordingly: a floxed conditional null builds tissue specific COX deficiency models, while hypomorphic knockins reproduce partial cofactor synthesis. No paralog performs this farnesylation. Pair Ckmm-Cre, Nes-Cre, or Camk2a-Cre with COX and SDH histochemistry, spectrophotometric complex IV activity, and blue native assembly analysis.
What Cox10 mouse models are available?
ingenious targeting laboratory offers 3 distinct Cox10 (COX10) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Cox10 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Cox10 allele types
Knockout, conditional, knockin, humanized, and related paths for Cox10 (human COX10). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Cox10 catalog models
3 Cox10 lines with QC documentation and technical support. Cox10 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Cox10 mouse model?
We have 3 Cox10 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Cox10 Mouse Model Types
A Cox10 knockout mouse has the Cox10 gene permanently inactivated, enabling loss of function studies. A Cox10 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Cox10, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Cox10 organized by modification type. Each URL is indexable and matches common search patterns.