Conventional / global / constitutive KO
●2 Models Available
Cox11 Conditional Knockout, Knockout mouse models
Browse 2 Cox11 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Cox11 conditional knockout mouse, Cox11 knockout mouse. Request a quote within 24 hours.
Why model Cox11
Cox11, ortholog of human COX11, encodes an inner membrane metallochaperone that receives copper from the intermembrane space carrier Cox17 through conserved cysteine thiols and inserts it into the CuB site of MT-CO1, the site that together with heme a3 forms the binuclear oxygen reduction center of cytochrome c oxidase. Because CuB delivery occurs as MT-CO1 is being inserted, loss of Cox11 arrests complex IV assembly at an early module and triggers turnover of unmetalated subunit 1, yielding isolated cytochrome c oxidase deficiency rather than a partial activity defect. That places the design fork between a conditional null, which produces tissue restricted COX deficiency, and cysteine substitution knockins, which test metal transfer chemistry specifically. Sco1, Sco2, and Cox19 act on the CuA site and do not substitute for CuB delivery. Use Ckmm-Cre or Nes-Cre with COX histochemistry, mitochondrial copper measurements, and blue native profiling of assembly intermediates.
What Cox11 mouse models are available?
ingenious targeting laboratory offers 2 distinct Cox11 (COX11) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Cox11 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Cox11 allele types
Knockout, conditional, knockin, humanized, and related paths for Cox11 (human COX11). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Cox11 catalog models
2 Cox11 lines with QC documentation and technical support. Cox11 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Cox11 mouse model?
We have 2 Cox11 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Cox11 Mouse Model Types
A Cox11 knockout mouse has the Cox11 gene permanently inactivated, enabling loss of function studies. A Cox11 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Cox11, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Cox11 organized by modification type. Each URL is indexable and matches common search patterns.