Conventional / global / constitutive KO
●2 Models Available
Gdf2 Conditional Knockout, Knockout mouse models
Browse 2 Gdf2 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Gdf2 conditional knockout mouse, Gdf2 knockout mouse. Contact us for availability and fast turnaround.
Why model Gdf2
Gdf2 is the mouse ortholog of human GDF2 and encodes BMP9, a circulating BMP produced largely by hepatic stellate cells that binds ALK1 with subnanomolar affinity, partners with BMPR2 or ActRIIA, and requires endoglin as coreceptor to phosphorylate SMAD1, SMAD5, and SMAD8 in endothelium, where it enforces quiescence and restrains angiogenic sprouting. Human loss-of-function alleles cause hereditary hemorrhagic telangiectasia type 5 and predispose to pulmonary arterial hypertension, mirroring the ALK1 and endoglin arm of the same axis. Conditional deletion in hepatocytes or stellate cells tests whether the liver is the obligate source of ligand, patient missense knockins probe prodomain processing and receptor engagement, and epitope humanization enables pharmacology of ALK1 pathway biologics. Redundancy here is genuine, since BMP10 signals through the same receptor set and circulates as a BMP9 and BMP10 heterodimer, so plan compound Gdf2 and Bmp10 alleles before concluding that single-gene loss is phenotypically silent.
What Gdf2 mouse models are available?
ingenious targeting laboratory offers 2 distinct Gdf2 (BMP9) catalog mouse models in the BMP/GDF family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Gdf2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Gdf2 allele types
Knockout, conditional, knockin, humanized, and related paths for Gdf2 (human GDF2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Gdf2 catalog models
2 Gdf2 lines with QC documentation and technical support. Gdf2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Gdf2 mouse model?
We have 2 Gdf2 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Gdf2 Mouse Model Types
A Gdf2 knockout mouse has the Gdf2 gene permanently inactivated, enabling loss of function studies. A Gdf2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Gdf2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Gdf2 organized by modification type. Each URL is indexable and matches common search patterns.