Conventional / global / constitutive KO
●2 Models Available
Gdf9 Conditional Knockout, Knockout mouse models
Browse 2 Gdf9 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Gdf9 conditional knockout mouse, Gdf9 knockout mouse. Contact us for availability and fast turnaround.
Why model Gdf9
Gdf9, ortholog of human GDF9, encodes an oocyte-restricted TGF-beta ligand that is unusual in signaling through BMPR2 paired with ALK5 to phosphorylate SMAD2 and SMAD3 in granulosa cells, and that forms the potent cumulin heterodimer with BMP15 to amplify cumulus expansion and metabolic support of the oocyte. Follicles arrest at the primary stage without it, so nulls are viable yet female sterile, and human variants cause premature ovarian insufficiency and influence dizygotic twinning rates. Because germline deletion already terminates folliculogenesis, oocyte-specific conditional deletion using Zp3-Cre or Gdf9-Cre is the way to interrogate later antral and periovulatory functions, patient missense knockins separate reduced secretion from impaired heterodimer assembly, and humanization enables recombinant cumulin and antibody assays. Bmp15 is the functional partner rather than a simple backup, and its dosage strongly modifies Gdf9 phenotypes, so compound allelic series are essential for meaningful fertility endpoints.
What Gdf9 mouse models are available?
ingenious targeting laboratory offers 2 distinct Gdf9 (GDF9) catalog mouse models in the BMP/GDF family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Gdf9 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Gdf9 allele types
Knockout, conditional, knockin, humanized, and related paths for Gdf9 (human GDF9). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Gdf9 catalog models
2 Gdf9 lines with QC documentation and technical support. Gdf9 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Gdf9 mouse model?
We have 2 Gdf9 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Gdf9 Mouse Model Types
A Gdf9 knockout mouse has the Gdf9 gene permanently inactivated, enabling loss of function studies. A Gdf9 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Gdf9, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Gdf9 organized by modification type. Each URL is indexable and matches common search patterns.