Conventional / global / constitutive KO
●3 Models Available
Gdf15 Conditional Knockout, Knockout mouse models
Browse 3 Gdf15 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Gdf15 conditional knockout mouse, Gdf15 knockout mouse. Request a quote within 24 hours.
Why model Gdf15
As the most divergent member of the TGF-beta superfamily, the mouse ortholog of human GDF15, Gdf15, produces a circulating hormone that signals not through canonical type II receptors but through GFRAL, a GDNF-receptor-family protein restricted to the area postrema and nucleus tractus solitarius, using RET as its signaling coreceptor. Transcription is driven by the integrated stress response through ATF4 and CHOP, and by p53, which is why plasma levels track mitochondrial disease, metformin exposure, and tumor burden, and why the ligand produces anorexia, nausea-like behavior, and cachexia. Germline nulls are viable, so straight knockouts remain informative, but tissue-restricted conditional deletion is needed to assign hepatic, placental, or tumor sources of the circulating pool. Alternatively, hepatocyte-directed overexpression or humanized knockins allow direct testing of blocking antibodies and long-acting agonists. No close paralog substitutes for this ligand, so single-locus loss is interpretable, and pairing it with Gfral alleles cleanly separates ligand supply from central reception.
What Gdf15 mouse models are available?
ingenious targeting laboratory offers 3 distinct Gdf15 (GDF15) catalog mouse models in the BMP/GDF family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Gdf15 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Gdf15 allele types
Knockout, conditional, knockin, humanized, and related paths for Gdf15 (human GDF15). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Gdf15 catalog models
3 Gdf15 lines with QC documentation and technical support. Gdf15 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Gdf15 mouse model?
We have 3 Gdf15 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Gdf15 Mouse Model Types
A Gdf15 knockout mouse has the Gdf15 gene permanently inactivated, enabling loss of function studies. A Gdf15 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Gdf15, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Gdf15 organized by modification type. Each URL is indexable and matches common search patterns.