Conventional / global / constitutive KO
●2 Models Available
Gdf3 Conditional Knockout, Knockout mouse models
Browse 2 Gdf3 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Gdf3 conditional knockout mouse, Gdf3 knockout mouse. Request a quote within 24 hours.
Why model Gdf3
Gdf3, ortholog of human GDF3, encodes a divergent TGF-beta ligand expressed in the inner cell mass, embryonic stem cells, and adipose tissue that behaves context-dependently, either signaling like Nodal through ActRIIB and ALK4 with an EGF-CFC coreceptor, or acting as an extracellular BMP antagonist that sequesters BMP4. This dual character explains why loss produces partially penetrant defects in anterior visceral endoderm positioning and mesoderm patterning rather than one clean phenotype, and why human variants segregate with microphthalmia, coloboma, and Klippel-Feil vertebral fusion. Conditional nulls address tissue-specific requirements in visceral endoderm versus adipocytes, knocking in patient missense alleles distinguishes a hypomorphic ligand from a true antimorph, and humanization supports biochemical assays of receptor and BMP binding. Because Gdf1 is the closest paralog and both ligands feed Nodal-type signaling, interpret single-locus phenotypes cautiously and build compound Gdf1 alleles whenever laterality or axial patterning is the endpoint.
What Gdf3 mouse models are available?
ingenious targeting laboratory offers 2 distinct Gdf3 (GDF3) catalog mouse models in the BMP/GDF family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Gdf3 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Gdf3 allele types
Knockout, conditional, knockin, humanized, and related paths for Gdf3 (human GDF3). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Looking for a Gdf3 mouse model?
We have 2 Gdf3 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Gdf3 Mouse Model Types
A Gdf3 knockout mouse has the Gdf3 gene permanently inactivated, enabling loss of function studies. A Gdf3 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Gdf3, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Gdf3 organized by modification type. Each URL is indexable and matches common search patterns.