Conventional / global / constitutive KO
●2 Models Available
Ndufb8 Conditional Knockout, Knockout mouse models
Browse 2 Ndufb8 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Ndufb8 conditional knockout mouse, Ndufb8 knockout mouse. Contact us for availability and fast turnaround.
Why model Ndufb8
Ndufb8, ortholog of human NDUFB8, encodes the ASHI subunit of complex I, a membrane arm accessory protein of the distal ND module whose abundance is unusually informative experimentally, since NDUFB8 immunolabeling paired with SDHA forms the standard quadruple immunofluorescence readout used to detect complex I deficiency in patient and mouse tissue at single-cell resolution. Biallelic human variants cause complex I deficiency with Leigh-like encephalopathy, and loss destabilizes the holoenzyme while subassemblies persist. This dual role as structural subunit and diagnostic marker has a practical consequence: any allele that removes or alters the epitope invalidates the very assay commonly used to phenotype it, so tagged or humanized knockins must be designed with antibody epitopes deliberately preserved or matched. A conditional null with neuronal or muscle Cre remains the tool for threshold mapping. Align allele with endpoints including quadruple immunofluorescence, BN-PAGE with in-gel activity, respirometry, and neuropathological lesion scoring.
What Ndufb8 mouse models are available?
ingenious targeting laboratory offers 2 distinct Ndufb8 (NDUFB8) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Ndufb8 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Ndufb8 allele types
Knockout, conditional, knockin, humanized, and related paths for Ndufb8 (human NDUFB8). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Ndufb8 catalog models
2 Ndufb8 lines with QC documentation and technical support. Ndufb8 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Ndufb8 mouse model?
We have 2 Ndufb8 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Ndufb8 Mouse Model Types
A Ndufb8 knockout mouse has the Ndufb8 gene permanently inactivated, enabling loss of function studies. A Ndufb8 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Ndufb8, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Ndufb8 organized by modification type. Each URL is indexable and matches common search patterns.