Conventional / global / constitutive KO
●1 Model Available
READY TO SHIP!
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Ndufa12 Conditional Knockout mouse model
Browse 1 Ndufa12 mouse model including conditional knockout variants from ingenious targeting laboratory. Contact us for availability and fast turnaround.
Why model Ndufa12
Final maturation of complex I depends on Ndufa12, the mouse ortholog of human NDUFA12, which encodes the B17.2 subunit added late to the N module of complex I, capping the peripheral arm once the FMN and iron-sulfur chain are in place, and it must be distinguished from its paralogous assembly chaperone NDUFAF2, formerly B17.2L, which transiently occupies the same site during biogenesis. Human NDUFA12 loss causes Leigh syndrome and optic atrophy with isolated complex I deficiency, and cells lacking it retain a nearly complete but functionally impaired enzyme, indicating a role in the terminal capping step and in stabilizing electron flow toward quinone. This makes a null allele genuinely informative, since the resulting phenotype is a misfinished rather than absent complex, while patient knockins allow allele-specific severity comparisons. The NDUFAF2 relationship is the real caution here, since retained chaperone occupancy can blunt phenotypes. Align allele with endpoints including in-gel activity, NDUFAF2 retention assays, retinal ganglion cell counts, and brainstem lesion progression.
What Ndufa12 mouse models are available?
ingenious targeting laboratory offers 1 distinct Ndufa12 (NDUFA12) catalog mouse model, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Ndufa12 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Ndufa12 allele types
Knockout, conditional, knockin, humanized, and related paths for Ndufa12 (human NDUFA12). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Ndufa12 catalog models
1 Ndufa12 line with QC documentation and technical support. Ndufa12 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Ndufa12-Flox
CKOCKO
These mice carry loxP sites flanking exon2 of Ndufa12 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Ndufa12 gene.
In DevelopmentCKO 263457
Looking for a Ndufa12 mouse model?
We have 1 Ndufa12 model available — including Conditional Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model1
Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Ndufa12 Mouse Model Types
A Ndufa12 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Ndufa12, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Ndufa12 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ITL
Send the Ndufa12 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.