Conventional / global / constitutive KO
●2 Models Available
READY TO SHIP!
LIVE · SPERM
Ndufs4 Conditional Knockout, Knockout mouse models
Browse 2 Ndufs4 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Ndufs4 conditional knockout mouse, Ndufs4 knockout mouse. Request a quote within 24 hours.
Why model Ndufs4
Ndufs4, the mouse ortholog of human NDUFS4, encodes an accessory subunit required for final assembly and stabilization of the complex I N module, the flavin-containing NADH oxidation domain, and it is a substrate for PKA-dependent phosphorylation that tunes holoenzyme stability. Loss does not abolish the enzyme outright but leaves a stalled subcomplex lacking NDUFV1, NDUFV2 and NDUFS6, so NADH oxidation fails while membrane arm subunits persist. Constitutive nulls are viable at birth and then develop progressive ataxia, breathing abnormalities and brainstem and cerebellar lesions, giving one of the most faithful Leigh syndrome models available and a proven platform for interventions such as mTOR inhibition or chronic hypoxia. Conditional floxed alleles let the neuron versus glia versus muscle question be separated, since whole-body loss confounds cell-autonomous interpretation. Choose the conditional null with a defined neuronal Cre for lesion mapping, and reserve the germline null for survival and therapeutic response endpoints.
What Ndufs4 mouse models are available?
ingenious targeting laboratory offers 2 distinct Ndufs4 (NDUFS4) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Ndufs4 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Ndufs4 allele types
Knockout, conditional, knockin, humanized, and related paths for Ndufs4 (human NDUFS4). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Ndufs4 catalog models
2 Ndufs4 lines with QC documentation and technical support. Ndufs4 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Ndufs4-Flox
CKOCKO
These mice carry loxP sites flanking exon 2 of Ndufs4 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Ndufs4 gene.
LiveCKO 253487 - Order
Ndufs4-KO
KOKO, Disease Model
Exon 2 of Ndufs4 gene was deleted to generate Ndufs4 knockout mice.
Sperm CryopreservedKO 201311
Looking for a Ndufs4 mouse model?
We have 2 Ndufs4 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Ndufs4 Mouse Model Types
A Ndufs4 knockout mouse has the Ndufs4 gene permanently inactivated, enabling loss of function studies. A Ndufs4 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Ndufs4, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Ndufs4 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Ndufs4 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.