Conventional / global / constitutive KO
●2 Models Available
Ndufa4 Conditional Knockout, Knockout mouse models
Browse 2 Ndufa4 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Ndufa4 conditional knockout mouse, Ndufa4 knockout mouse. Contact us for availability and fast turnaround.
Why model Ndufa4
Despite its name, Ndufa4, the mouse ortholog of human NDUFA4, encodes a subunit reassigned from complex I to complex IV, where it binds the cytochrome c oxidase monomer and prevents dimerization, acting as a bona fide fourteenth COX subunit that modulates catalytic efficiency. Human biallelic NDUFA4 variants cause Leigh syndrome with isolated complex IV deficiency, consistent with that reassignment and providing a rare case in which the gene name actively misdirects experimental design. Allele planning should therefore be built around complex IV endpoints, with a conditional null using neuronal or cardiac Cre to test tissue thresholds for COX activity and patient variant knockins to model the hypomorphic human state. Importantly, the paralog Ndufa4l2 is induced by HIF1A in hypoxic and tumor tissue and substitutes at the same site with altered kinetics, so compound or hypoxia-controlled designs are necessary to avoid masked phenotypes. Match allele to COX histochemistry, monomer to dimer ratios, respirometry, or Leigh-like lesion imaging.
What Ndufa4 mouse models are available?
ingenious targeting laboratory offers 2 distinct Ndufa4 (NDUFA4) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Ndufa4 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Ndufa4 allele types
Knockout, conditional, knockin, humanized, and related paths for Ndufa4 (human NDUFA4). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Ndufa4 catalog models
2 Ndufa4 lines with QC documentation and technical support. Ndufa4 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Ndufa4 mouse model?
We have 2 Ndufa4 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Ndufa4 Mouse Model Types
A Ndufa4 knockout mouse has the Ndufa4 gene permanently inactivated, enabling loss of function studies. A Ndufa4 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Ndufa4, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Ndufa4 organized by modification type. Each URL is indexable and matches common search patterns.