Conventional / global / constitutive KO
●2 Models Available
Ndufs2 Conditional Knockout, Knockout mouse models
Browse 2 Ndufs2 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Ndufs2 conditional knockout mouse, Ndufs2 knockout mouse. Contact us for availability and fast turnaround.
Why model Ndufs2
Encoding the mouse ortholog of human NDUFS2, Ndufs2 specifies the 49 kDa core subunit that, together with NDUFS7, NDUFS3 and ND1, builds the quinone-binding chamber of complex I, shaping the terminal N2 cluster environment and coupling quinone reduction to the conformational changes that drive proton translocation in the membrane arm. Biallelic human variants cause Leigh syndrome, hypertrophic cardiomyopathy and optic atrophy with isolated complex I deficiency, and structural work shows that Q-site mutations can uncouple electron transfer from pumping rather than simply reducing enzyme amount. That mechanism argues for patient missense knockins when the goal is to model partial, uncoupled activity, and for conditional nulls with cardiomyocyte, neuronal or retinal Cre when the question is tissue tolerance of complex I loss, since a germline null is not viable. No paralog substitutes for a core subunit. Choose endpoints separating coupling from capacity, including proton pumping and membrane potential, quinone site inhibitor sensitivity, respirometry, echocardiography, and retinal ganglion cell quantification.
What Ndufs2 mouse models are available?
ingenious targeting laboratory offers 2 distinct Ndufs2 (NDUFS2) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Ndufs2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Ndufs2 allele types
Knockout, conditional, knockin, humanized, and related paths for Ndufs2 (human NDUFS2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Ndufs2 catalog models
2 Ndufs2 lines with QC documentation and technical support. Ndufs2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Ndufs2 mouse model?
We have 2 Ndufs2 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Ndufs2 Mouse Model Types
A Ndufs2 knockout mouse has the Ndufs2 gene permanently inactivated, enabling loss of function studies. A Ndufs2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Ndufs2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Ndufs2 organized by modification type. Each URL is indexable and matches common search patterns.