Conventional / global / constitutive KO
●2 Models Available
Wnt11 Conditional Knockout, Knockout mouse models
Browse 2 Wnt11 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Wnt11 conditional knockout mouse, Wnt11 knockout mouse. Contact us for availability and fast turnaround.
Why model Wnt11
Predominantly noncanonical in output, Wnt11 is the mouse ortholog of human WNT11 and signals through Frizzled 7 with the alternative receptors ROR2 and RYK to activate RHOA, ROCK, DAAM1, and JNK, driving planar polarity and calcium-dependent responses rather than beta-catenin stabilization, and it can antagonize canonical output in the same tissue. In the kidney it sits in a reciprocal loop with GDNF and RET in the ureteric bud tip, so nulls show reduced branching, nephron deficit, and renal hypoplasia with perinatal compromise, alongside reported outflow tract and myocardial defects. Ureteric epithelium conditional deletion with Hoxb7-Cre separates tip-autonomous requirement from metanephric mesenchyme signaling, knockins that disrupt ROR2 engagement test receptor selectivity, and humanization supports biochemical assays. Wnt5a supplies overlapping polarity input in most of these tissues, so compound Wnt5a alleles are worth planning before ascribing convergent extension defects to Wnt11 alone.
What Wnt11 mouse models are available?
ingenious targeting laboratory offers 2 distinct Wnt11 (WNT11) catalog mouse models in the Wnt family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Wnt11 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Wnt11 allele types
Knockout, conditional, knockin, humanized, and related paths for Wnt11 (human WNT11). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Wnt11 catalog models
2 Wnt11 lines with QC documentation and technical support. Wnt11 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Wnt11 mouse model?
We have 2 Wnt11 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Wnt11 Mouse Model Types
A Wnt11 knockout mouse has the Wnt11 gene permanently inactivated, enabling loss of function studies. A Wnt11 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Wnt11, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Wnt11 organized by modification type. Each URL is indexable and matches common search patterns.