Conventional / global / constitutive KO
●2 Models Available
READY TO SHIP!
SPERM · DEVELOPING
Wnt3a Conditional Knockout, Knockout mouse models
Browse 2 Wnt3a mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Wnt3a conditional knockout mouse, Wnt3a knockout mouse. Contact us for availability and fast turnaround.
Why model Wnt3a
Widely supplied as the recombinant canonical ligand of choice, Wnt3a is the mouse ortholog of human WNT3A and stabilizes beta-catenin through Frizzled with LRP6 to maintain the primitive streak after initiation, sustain neuromesodermal progenitors, and drive paraxial mesoderm and somitogenesis, with an additional requirement in hippocampal development alongside LEF1. Nulls truncate the caudal axis with absent tailbud somites and die in late gestation, whereas the spontaneous vestigial tail allele is hypomorphic and survives, providing a natural allelic series that argues for dose-graded engineering rather than a single null. Conditional deletion isolates progenitor pool maintenance from later neural roles, hypomorphic knockins titrate signaling output against segment number, and humanization supports agonist and surrogate ligand testing. Wnt3 overlaps in axis programs and Wnt5a contributes to elongation, so pair conditional alleles with a validated posterior driver and a beta-catenin reporter to quantify actual pathway dose.
What Wnt3a mouse models are available?
ingenious targeting laboratory offers 2 distinct Wnt3a (WNT3A) catalog mouse models in the Wnt family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Wnt3a model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Wnt3a allele types
Knockout, conditional, knockin, humanized, and related paths for Wnt3a (human WNT3A). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Wnt3a catalog models
2 Wnt3a lines with QC documentation and technical support. Wnt3a floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Wnt3a-Flox
CKOCKO
These mice carry loxP sites flanking exon2 of Wnt3a gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Wnt3a gene.
In DevelopmentCKO 264040 - Order
Wnt3a-KO
KOKO
The exon 2 of Wnt3a gene was deleted to generate Wnt3a knockout mouse.
Sperm CryopreservedKO 234571
Looking for a Wnt3a mouse model?
We have 2 Wnt3a models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Wnt3a Mouse Model Types
A Wnt3a knockout mouse has the Wnt3a gene permanently inactivated, enabling loss of function studies. A Wnt3a conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Wnt3a, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Wnt3a organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Wnt3a line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.