Conventional / global / constitutive KO
●2 Models Available
Wnt2 Conditional Knockout, Knockout mouse models
Browse 2 Wnt2 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Wnt2 conditional knockout mouse, Wnt2 knockout mouse. Contact us for availability and fast turnaround.
Why model Wnt2
Wnt2 is the mouse ortholog of human WNT2 and encodes a canonical ligand of splanchnic mesenchyme that stabilizes beta-catenin through Frizzled with LRP6 in lung mesenchyme, where it specifies Nkx2-1 positive respiratory progenitors from foregut endoderm, and in placental and cardiac progenitor populations. The original null was recognized through placental vascular insufficiency with partial perinatal loss, while lung specification appears grossly intact on its own, which is the key design consideration. Mesenchyme-restricted conditional deletion using Dermo1-Cre or Tbx4 enhancer drivers addresses stage-specific requirements once placental confounding is removed, and humanized alleles support agonist and Porcupine inhibitor pharmacology. Redundancy here is not hypothetical, since Wnt2b is coexpressed in the same ventral foregut mesenchyme and only compound Wnt2 and Wnt2b nulls abolish lung specification and produce lung agenesis. Plan the double conditional and a validated mesenchymal driver from the start rather than after a disappointing single-locus result.
What Wnt2 mouse models are available?
ingenious targeting laboratory offers 2 distinct Wnt2 (WNT2) catalog mouse models in the Wnt family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Wnt2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Wnt2 allele types
Knockout, conditional, knockin, humanized, and related paths for Wnt2 (human WNT2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Wnt2 catalog models
2 Wnt2 lines with QC documentation and technical support. Wnt2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Wnt2 mouse model?
We have 2 Wnt2 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Wnt2 Mouse Model Types
A Wnt2 knockout mouse has the Wnt2 gene permanently inactivated, enabling loss of function studies. A Wnt2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Wnt2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Wnt2 organized by modification type. Each URL is indexable and matches common search patterns.