Conventional / global / constitutive KO
●1 Model Available
READY TO SHIP!
IN PRODUCTION
Wnt3 Knockout mouse model
Browse 1 Wnt3 mouse model including knockout variants — in stock and ready to ship from ingenious targeting laboratory. Request a quote within 24 hours.
Why model Wnt3
Wnt3 is the mouse ortholog of human WNT3 and encodes the canonical ligand that initiates the mouse body axis, acting through Frizzled with LRP5 or LRP6 to stabilize beta-catenin and induce primitive streak formation in the posterior epiblast. Nulls arrest at gastrulation without a streak or mesoderm, an absolute early embryonic lethality that forces conditional and inducible designs for any later question, and human mutations cause tetra-amelia with craniofacial and urogenital malformation, indicating persistent limb induction requirements. Conditional deletion with Sox2-Cre, T-Cre, or tamoxifen-inducible drivers separates epiblast axis initiation from later limb and hair follicle roles, tetra-amelia knockins test whether human variants are secretion defective, and humanization supports pathway agonist testing. Wnt3a cannot substitute at streak initiation despite sharing receptors and acting later in axis elongation, so treat the two as sequential rather than interchangeable and time Cre activity precisely against the streak stage.
What Wnt3 mouse models are available?
ingenious targeting laboratory offers 1 distinct Wnt3 (WNT3) catalog mouse model in the Wnt family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Wnt3 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Wnt3 allele types
Knockout, conditional, knockin, humanized, and related paths for Wnt3 (human WNT3). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Wnt3 catalog models
1 Wnt3 line with QC documentation and technical support.
- Order
Wnt3-KO
KOKO
The exon2 of Wnt3 gene was deleted to generate Wnt3 knockout mouse.
In production — inquireKO 262330
Looking for a Wnt3 mouse model?
We have 1 Wnt3 model in stock — including Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model1
Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Wnt3 Mouse Model Types
A Wnt3 knockout mouse has the Wnt3 gene permanently inactivated, enabling loss of function studies.
Modifications available
Jump to catalog backed pages for Wnt3 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ITL
Send the Wnt3 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.