Conventional / global / constitutive KO
●1 Model Available
READY TO SHIP!
DEVELOPING
Wnt16 Knockout mouse model
Browse 1 Wnt16 mouse model including knockout variants from ingenious targeting laboratory. Contact us for availability and fast turnaround.
Why model Wnt16
Cortical bone is the compartment where Wnt16, the mouse ortholog of human WNT16, exerts its effect, since this osteoblast-derived Wnt signals through Frizzled with LRP5 or LRP6 and also engages noncanonical routes to suppress osteoclastogenesis both directly, by blunting RANKL-driven differentiation, and indirectly through osteoprotegerin induction. Human variation at the locus is among the strongest determinants of cortical bone mineral density and forearm fracture risk, and nulls are viable with thin, porous cortices and spontaneous fractures despite largely preserved trabecular bone, a compartment-selective phenotype that makes the gene valuable for skeletal fragility work. Osteoblast or osteocyte conditional deletion with Col1a1-Cre or Dmp1-Cre establishes cell of origin, gain-of-function knockins test whether restoring ligand suffices to thicken cortex, and humanization enables pathway agonist pharmacology. Redundancy is limited in the periosteal compartment, which is precisely why single-locus loss gives a clean readout, so cortical geometry and fracture endpoints remain directly interpretable.
What Wnt16 mouse models are available?
ingenious targeting laboratory offers 1 distinct Wnt16 (WNT16) catalog mouse model in the Wnt family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Wnt16 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Wnt16 allele types
Knockout, conditional, knockin, humanized, and related paths for Wnt16 (human WNT16). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Wnt16 catalog models
1 Wnt16 line with QC documentation and technical support.
- Order
Wnt16-KO
KOKO
The exon3 of Wnt16 gene was deleted to generate Wnt16 knockout mouse.
In DevelopmentKO 262345
Looking for a Wnt16 mouse model?
We have 1 Wnt16 model available — including Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Wnt16 Mouse Model Types
A Wnt16 knockout mouse has the Wnt16 gene permanently inactivated, enabling loss of function studies.
Modifications available
Jump to catalog backed pages for Wnt16 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ITL
Send the Wnt16 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.