Conventional / global / constitutive KO
●2 Models Available
Wnt4 Conditional Knockout, Knockout mouse models
Browse 2 Wnt4 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Wnt4 conditional knockout mouse, Wnt4 knockout mouse. Request a quote within 24 hours.
Why model Wnt4
Wnt4 is the mouse ortholog of human WNT4 and encodes a ligand operating in both canonical and noncanonical modes, whose defining role is enforcing the ovarian program, since with RSPO1 it sustains beta-catenin in the XX gonad to suppress SOX9 and FGF9, while it also drives Mullerian duct development, adrenal cortex organization, and the mesenchymal to epithelial transition of pretubular aggregates in the nephron lineage. Nulls die perinatally with renal agenesis and partial XX masculinization, human loss of function causes SERKAL syndrome with female to male sex reversal plus renal, adrenal, and pulmonary dysgenesis, and heterozygous variants appear in Mullerian aplasia. Conditional deletion with Sf1-Cre for gonad and adrenal or Six2-Cre and Pax2-Cre for nephron progenitors separates these requirements, and SERKAL knockins test residual activity. Wnt9b overlaps in duct elongation, so compound alleles matter when urogenital tract endpoints, rather than gonadal fate, are primary.
What Wnt4 mouse models are available?
ingenious targeting laboratory offers 2 distinct Wnt4 (WNT4) catalog mouse models in the Wnt family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Wnt4 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Wnt4 allele types
Knockout, conditional, knockin, humanized, and related paths for Wnt4 (human WNT4). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Wnt4 catalog models
2 Wnt4 lines with QC documentation and technical support. Wnt4 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Wnt4 mouse model?
We have 2 Wnt4 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Wnt4 Mouse Model Types
A Wnt4 knockout mouse has the Wnt4 gene permanently inactivated, enabling loss of function studies. A Wnt4 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Wnt4, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Wnt4 organized by modification type. Each URL is indexable and matches common search patterns.