Conventional / global / constitutive KO
●2 Models Available
Wnt5a Conditional Knockout, Knockout mouse models
Browse 2 Wnt5a mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Wnt5a conditional knockout mouse, Wnt5a knockout mouse. Contact us for availability and fast turnaround.
Why model Wnt5a
Wnt5a, the mouse ortholog of human WNT5A, encodes the prototypical noncanonical Wnt and signals through Frizzled with the alternative receptors ROR2 and RYK to engage VANGL2, Dishevelled, RHOA, ROCK, and JNK, directing planar polarity and convergent extension while frequently antagonizing beta-catenin-dependent transcription in the same tissue. Nulls die perinatally with severe anterior to posterior truncation, shortened limbs and digits, and craniofacial and genital defects, phenocopying the Ror2 mutant and matching human disease, since heterozygous WNT5A mutations cause dominant Robinow syndrome while recessive ROR2 mutations cause the recessive form. Conditional deletion is therefore required for postnatal work in lung, mammary gland, and tumor stroma, patient cysteine substitution knockins test ligand and receptor coupling rather than absence, and humanization supports pathway pharmacology. Wnt11 and Wnt5b provide overlapping polarity input, so compound conditional alleles and a lineage-validated Cre driver protect against under-reading a real requirement.
What Wnt5a mouse models are available?
ingenious targeting laboratory offers 2 distinct Wnt5a (WNT5A) catalog mouse models in the Wnt family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Wnt5a model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Wnt5a allele types
Knockout, conditional, knockin, humanized, and related paths for Wnt5a (human WNT5A). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Wnt5a catalog models
2 Wnt5a lines with QC documentation and technical support. Wnt5a floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Wnt5a mouse model?
We have 2 Wnt5a models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Wnt5a Mouse Model Types
A Wnt5a knockout mouse has the Wnt5a gene permanently inactivated, enabling loss of function studies. A Wnt5a conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Wnt5a, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Wnt5a organized by modification type. Each URL is indexable and matches common search patterns.