Conventional / global / constitutive KO
●3 Models Available
Fgf1 Conditional Knockout, Knockout mouse models
Browse 3 Fgf1 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Fgf1 conditional knockout mouse, Fgf1 knockout mouse. Contact us for availability and fast turnaround.
Why model Fgf1
Fgf1, mouse ortholog of human FGF1 and historically acidic FGF, encodes the most promiscuous ligand of the family, capable of activating all seven principal FGFR splice variants when presented with heparan sulfate, which drives FRS2 recruitment, RAS to ERK signaling, PI3K, and PLCgamma output. It carries no signal peptide and exits cells by a nonclassical copper-dependent route involving S100A13 and synaptotagmin, and its intracellular pool binds FIBP and can traffic to the nucleus. Nulls are viable with only subtle vascular and wound phenotypes, making constitutive deletion straightforward, so most designs instead pursue knockins of engineered variants: thermostable or heparin-binding-deficient mutants, or receptor-biased forms that retain glucose lowering without mitogenicity, since central administration produces sustained diabetes remission. Extensive redundancy with FGF2 and other paracrine ligands at shared receptors means single-locus loss rarely produces a clean readout. Choose conditional alleles when the endpoint is tissue-autonomous repair, and humanized knockins when profiling therapeutic FGF1 analogs.
What Fgf1 mouse models are available?
ingenious targeting laboratory offers 3 distinct Fgf1 (FGF1) catalog mouse models in the FGF family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Fgf1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Fgf1 allele types
Knockout, conditional, knockin, humanized, and related paths for Fgf1 (human FGF1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Fgf1 catalog models
3 Fgf1 lines with QC documentation and technical support. Fgf1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Fgf1 mouse model?
We have 3 Fgf1 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Fgf1 Mouse Model Types
A Fgf1 knockout mouse has the Fgf1 gene permanently inactivated, enabling loss of function studies. A Fgf1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Fgf1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Fgf1 organized by modification type. Each URL is indexable and matches common search patterns.