Conventional / global / constitutive KO
●2 Models Available
Fgf2 Conditional Knockout, Knockout mouse models
Browse 2 Fgf2 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Fgf2 conditional knockout mouse, Fgf2 knockout mouse. Contact us for availability and fast turnaround.
Why model Fgf2
Fgf2, mouse ortholog of human FGF2 and long called basic FGF, encodes a heparin-dependent ligand that activates FGFR1c and FGFR2c to drive FRS2, ERK, PI3K, and PLCgamma signaling, and it is stored bound to heparan sulfate proteoglycans in extracellular matrix, forming a mobilizable reservoir released by heparanase or injury. Translation from alternative CUG start codons yields high molecular weight isoforms that bear nuclear localization signals and act intracellularly, distinct from the classical 18 kDa form that is exported by a nonclassical, signal peptide independent route. Nulls are viable with reduced vascular tone, delayed wound healing, and neocortical neuron deficits, so constitutive deletion is feasible, but isoform-specific knockins that ablate only high molecular weight forms are far more revealing given their opposing roles in cardiac hypertrophy. Redundancy with FGF1 and other c-isoform ligands buffers single-locus loss. Use conditional alleles with Cdh5-CreER or Nestin-Cre when the endpoint is angiogenesis or neural progenitor expansion rather than systemic phenotype.
What Fgf2 mouse models are available?
ingenious targeting laboratory offers 2 distinct Fgf2 (FGF2) catalog mouse models in the FGF family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Fgf2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Fgf2 allele types
Knockout, conditional, knockin, humanized, and related paths for Fgf2 (human FGF2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Fgf2 catalog models
2 Fgf2 lines with QC documentation and technical support. Fgf2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Selected publications from ingenious targeting laboratory
Peer reviewed work involving Fgf2 (FGF2) from ITL supported projects.
- Differentiated embryo chondrocyte 1 (DEC1) is a novel negative regulator of hepatic fibroblast growth factor 21 (FGF21) in aging miceFujita Y, Makishima M, Bhawal UK. (2016). Biochem Biophys Res Commun 269(3): 477-82
Looking for a Fgf2 mouse model?
We have 2 Fgf2 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Fgf2 Mouse Model Types
A Fgf2 knockout mouse has the Fgf2 gene permanently inactivated, enabling loss of function studies. A Fgf2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Fgf2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Fgf2 organized by modification type. Each URL is indexable and matches common search patterns.