Conventional / global / constitutive KO
●2 Models Available
Fgf12 Conditional Knockout, Knockout mouse models
Browse 2 Fgf12 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Fgf12 conditional knockout mouse, Fgf12 knockout mouse. Request a quote within 24 hours.
Why model Fgf12
Fgf12, ortholog of human FGF12, encodes an intracellular FGF homologous factor, formerly FHF1, that is not secreted and does not activate FGFRs; instead its beta-trefoil core binds the C-terminal tail of voltage-gated sodium channels including NaV1.5 in heart and NaV1.2 and NaV1.6 in neurons, tuning fast inactivation kinetics, promoting long-term inactivation, and shifting availability, with an alternative N-terminal isoform determining the strength of that block. Human recurrent gain-of-function variants such as the arginine to histidine substitution in the core cause developmental and epileptic encephalopathy, while other variants associate with Brugada-type conduction phenotypes, so patient-specific missense knockins are the disease-relevant allele rather than a null. Constitutive deletion is viable and yields modest excitability changes, reflecting substantial redundancy with Fgf11, Fgf13, and Fgf14 in the same compartments, so compound genetics should be planned before interpreting seizure thresholds. Match allele class to endpoint: knockin for channel biophysics and EEG phenotypes, conditional flox with neuron or cardiomyocyte Cre for compartment attribution.
What Fgf12 mouse models are available?
ingenious targeting laboratory offers 2 distinct Fgf12 (FGF12) catalog mouse models in the FGF family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Fgf12 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Fgf12 allele types
Knockout, conditional, knockin, humanized, and related paths for Fgf12 (human FGF12). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Fgf12 catalog models
2 Fgf12 lines with QC documentation and technical support. Fgf12 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Fgf12 mouse model?
We have 2 Fgf12 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Fgf12 Mouse Model Types
A Fgf12 knockout mouse has the Fgf12 gene permanently inactivated, enabling loss of function studies. A Fgf12 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Fgf12, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Fgf12 organized by modification type. Each URL is indexable and matches common search patterns.