Conventional / global / constitutive KO
●2 Models Available
Fgf11 Conditional Knockout, Knockout mouse models
Browse 2 Fgf11 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Fgf11 conditional knockout mouse, Fgf11 knockout mouse. Contact us for availability and fast turnaround.
Why model Fgf11
Fgf11, the mouse ortholog of human FGF11, belongs to the intracellular FGF homologous factor subfamily and, despite the name, encodes no secreted mitogen: the protein lacks a signal peptide, does not engage FGFR ectodomains, and instead functions within the cytosol through a beta-trefoil core that docks onto the C-terminal tails of voltage-gated sodium channels and interacts with hypoxia-responsive machinery, having been described as a HIF-1alpha modulator in T cells and tumor contexts. This intracellular mechanism dictates allele strategy: secreted-ligand logic such as ligand traps or neutralizing antibodies is inapplicable, and interpretation should center on channel gating, cytoskeletal, and transcriptional readouts. Nulls are viable, so constitutive deletion is feasible, while domain-swap or interaction-surface point knockins are far more informative than whole-gene ablation for separating channel binding from other partners. The closely related paralogs Fgf12, Fgf13, and Fgf14 occupy overlapping neuronal and cardiac territory, so compound genetics is often required before assigning an excitability or arrhythmia endpoint to this locus.
What Fgf11 mouse models are available?
ingenious targeting laboratory offers 2 distinct Fgf11 (FGF11) catalog mouse models in the FGF family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Fgf11 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Fgf11 allele types
Knockout, conditional, knockin, humanized, and related paths for Fgf11 (human FGF11). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Fgf11 catalog models
2 Fgf11 lines with QC documentation and technical support. Fgf11 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Fgf11 mouse model?
We have 2 Fgf11 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Fgf11 Mouse Model Types
A Fgf11 knockout mouse has the Fgf11 gene permanently inactivated, enabling loss of function studies. A Fgf11 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Fgf11, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Fgf11 organized by modification type. Each URL is indexable and matches common search patterns.