Conventional / global / constitutive KO
●2 Models Available
Fgf18 Conditional Knockout, Knockout mouse models
Browse 2 Fgf18 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Fgf18 conditional knockout mouse, Fgf18 knockout mouse. Request a quote within 24 hours.
Why model Fgf18
Fgf18, ortholog of human FGF18, encodes a secreted FGF8 subfamily ligand that signals principally through FGFR3c and FGFR4, with additional FGFR1c and FGFR2c engagement, and functions as a positive regulator of chondrocyte proliferation, matrix production, and growth plate hypertrophic transition while simultaneously restraining osteoblast differentiation timing, thereby coordinating endochondral ossification and cranial suture closure. It is the basis of the intra-articular cartilage anabolic agent sprifermin, which makes species-matched receptor engagement a practical concern. Germline nulls die in the perinatal period with delayed ossification, expanded proliferative zones, and craniosynostosis-like suture abnormalities, so conditional floxed alleles combined with Col2a1-Cre, Prrx1-Cre, or Sp7-Cre are the appropriate tool for postnatal joint and skeletal work. Overlapping activity from Fgf9 at the same c-isoform receptors means compound conditionals are advisable when the endpoint is complete growth plate FGF input. Align allele class to readout: humanized knockins for sprifermin-type pharmacology, conditional deletion for cartilage homeostasis and osteoarthritis progression.
What Fgf18 mouse models are available?
ingenious targeting laboratory offers 2 distinct Fgf18 (FGF18) catalog mouse models in the FGF family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Fgf18 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Fgf18 allele types
Knockout, conditional, knockin, humanized, and related paths for Fgf18 (human FGF18). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Looking for a Fgf18 mouse model?
We have 2 Fgf18 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Fgf18 Mouse Model Types
A Fgf18 knockout mouse has the Fgf18 gene permanently inactivated, enabling loss of function studies. A Fgf18 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Fgf18, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Fgf18 organized by modification type. Each URL is indexable and matches common search patterns.