Conventional / global / constitutive KO
●2 Models Available
READY TO SHIP!
SPERM
Fgf16 Conditional Knockout, Knockout mouse models
Browse 2 Fgf16 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Fgf16 conditional knockout mouse, Fgf16 knockout mouse. Contact us for availability and fast turnaround.
Why model Fgf16
Fgf16, ortholog of human FGF16, encodes a secreted FGF9 subfamily ligand that, unlike most paracrine members, dimerizes in a way that limits heparan sulfate binding and diffusion, and it signals preferentially through FGFR1c, FGFR2c, FGFR3c, and FGFR4 with FRS2 to ERK output. Expression concentrates in embryonic and adult cardiomyocytes and brown adipose tissue, where it supports cardiomyocyte proliferation during ventricular growth and modulates hypertrophic and injury responses, and additional signal in developing limb correlates with human phenotypes. Hemizygous human loss-of-function variants cause X-linked metacarpal 4 and 5 fusion, and the mouse locus is likewise X-linked, so hemizygous male, homozygous female, and mosaic heterozygous female comparisons must be built into the design. Nulls are viable, making constitutive deletion tractable for cardiac stress testing, while conditional floxed alleles with Myh6-Cre or Adipoq-Cre attribute effects to muscle versus fat. Substantial overlap with Fgf9 and Fgf20 at shared c-isoform receptors argues for compound alleles when scoring proliferation endpoints.
What Fgf16 mouse models are available?
ingenious targeting laboratory offers 2 distinct Fgf16 (FGF16) catalog mouse models in the FGF family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Fgf16 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Fgf16 allele types
Knockout, conditional, knockin, humanized, and related paths for Fgf16 (human FGF16). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Fgf16 catalog models
2 Fgf16 lines with QC documentation and technical support. Fgf16 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Fgf16-Flox
CKOCKO
These strains carry loxP sites flanking exon 2-3 of Fgf16 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Fgf16 gene.
Sperm CryopreservedCKO 250164 - Order
Fgf16-KO
KOKO
The exon 2-3 of Fgf16 gene was deleted to generate Fgf16 knockout mouse.
Sperm CryopreservedKO 251414
Looking for a Fgf16 mouse model?
We have 2 Fgf16 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Fgf16 Mouse Model Types
A Fgf16 knockout mouse has the Fgf16 gene permanently inactivated, enabling loss of function studies. A Fgf16 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Fgf16, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Fgf16 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Fgf16 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.