Conventional / global / constitutive KO
●2 Models Available
Fgf10 Conditional Knockout, Knockout mouse models
Browse 2 Fgf10 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Fgf10 conditional knockout mouse, Fgf10 knockout mouse. Request a quote within 24 hours.
Why model Fgf10
Fgf10, ortholog of human FGF10, encodes a mesenchymally expressed paracrine ligand with strong heparan sulfate affinity that signals with high selectivity through the FGFR2b splice variant on adjacent epithelium, driving FRS2 to ERK output and constituting the reciprocal mesenchymal arm of the FGF10 to FGFR2b to SHH loop that governs branching morphogenesis. It is required for lung bud initiation and outgrowth, limb bud induction, and development of salivary, lacrimal, mammary, and pancreatic epithelium, and it maintains adult alveolar and airway progenitors. Germline nulls die at birth with complete lung agenesis and absent limbs, so conditional floxed alleles are mandatory for postnatal regeneration studies. Human heterozygous loss causes lacrimo-auriculo-dento-digital syndrome and aplasia of lacrimal and salivary glands, making hypomorphic or heterozygous designs the closer disease match. The related ligand FGF7 shares FGFR2b and can partially substitute in glandular epithelium, so compound alleles clarify attribution. Pair the flox with Tbx4-rtTA or Dermo1-Cre depending on the tissue endpoint.
What Fgf10 mouse models are available?
ingenious targeting laboratory offers 2 distinct Fgf10 (FGF10) catalog mouse models in the FGF family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Fgf10 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Fgf10 allele types
Knockout, conditional, knockin, humanized, and related paths for Fgf10 (human FGF10). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Fgf10 catalog models
2 Fgf10 lines with QC documentation and technical support. Fgf10 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Fgf10 mouse model?
We have 2 Fgf10 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Fgf10 Mouse Model Types
A Fgf10 knockout mouse has the Fgf10 gene permanently inactivated, enabling loss of function studies. A Fgf10 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Fgf10, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Fgf10 organized by modification type. Each URL is indexable and matches common search patterns.