Conventional / global / constitutive KO
●2 Models Available
Wnt5b Knockin, Knockout mouse models
Browse 2 Wnt5b mouse models including knockin, knockout variants from ingenious targeting laboratory. Available as Wnt5b knockin mouse, Wnt5b knockout mouse. Contact us for availability and fast turnaround.
Why model Wnt5b
Wnt5b is the mouse ortholog of human WNT5B and encodes the close paralog of WNT5A, sharing its lipidation and secretion requirements and its preference for noncanonical output through Frizzled with ROR2, activating RHOA, JNK, and calcium-dependent responses in growth plate chondrocytes, adipocyte progenitors, pancreatic islets, and digit mesenchyme. Nulls are grossly normal, which is the central design fact, because the informative experiment is almost never single-locus deletion but compound Wnt5a and Wnt5b genetics, where dosage reduction aggravates chondrocyte column disorganization and limb shortening beyond either single mutant. Accordingly, build a conditional Wnt5b allele intended for use on a Wnt5a-sensitized background, add overexpression knockins to test whether Wnt5b can substitute for Wnt5a when supplied in the correct domain, and humanize the ligand for receptor selectivity pharmacology. Pair these with a chondrocyte or limb mesenchyme driver, since interpretable skeletal endpoints depend on restricting deletion to the relevant lineage.
What Wnt5b mouse models are available?
ingenious targeting laboratory offers 2 distinct Wnt5b (WNT5B) catalog mouse models in the Wnt family, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Wnt5b model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Wnt5b allele types
Knockout, conditional, knockin, humanized, and related paths for Wnt5b (human WNT5B). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Looking for a Wnt5b mouse model?
We have 2 Wnt5b models available — including Knockin, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Wnt5b Mouse Model Types
A Wnt5b knockout mouse has the Wnt5b gene permanently inactivated, enabling loss of function studies. Wnt5b knockin models carry a precisely inserted sequence at the Wnt5b locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Wnt5b organized by modification type. Each URL is indexable and matches common search patterns.