Conventional / global / constitutive KO
●2 Models Available
Fgfr1 Conditional Knockout, Knockin mouse models
Browse 2 Fgfr1 mouse models including conditional knockout, knockin variants — in stock and ready to ship from ingenious targeting laboratory. Available as Fgfr1 conditional knockout mouse, Fgfr1 knockin mouse. Request a quote within 24 hours.
Why model Fgfr1
Fgfr1, mouse ortholog of human FGFR1, encodes a receptor tyrosine kinase with three immunoglobulin-like extracellular domains, an acid box, and a split intracellular kinase domain, requiring heparan sulfate proteoglycan as a ternary coreceptor for FGF binding and, for endocrine FGFs, klotho proteins. Alternative splicing of the second half of the third Ig domain generates IIIb and IIIc variants with divergent ligand specificity, and activated receptor recruits FRS2 alpha and PLC gamma to drive RAS-MAPK, PI3K and PKC output. Loss of function alleles cause Kallmann syndrome and hypogonadotropic hypogonadism, while activating P252R causes Pfeiffer syndrome and 8p11 fusions such as ZMYM2-FGFR1 drive myeloid neoplasms. Germline nulls die at gastrulation from failed mesodermal migration, so conditional floxed kinase domain alleles with lineage Cre are required. Fgfr2 and Fgfr3 overlap in ligand response and compensate in limb and skeleton, so compound alleles matter. Use isoform-restricted or point knockins when splice-specific or inhibitor questions drive the study.
What Fgfr1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Fgfr1 (FGFR1) catalog mouse models, featuring conditional knockout and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Fgfr1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Fgfr1 allele types
Knockout, conditional, knockin, humanized, and related paths for Fgfr1 (human FGFR1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Fgfr1 catalog models
2 Fgfr1 lines with QC documentation and technical support. Fgfr1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Fgfr1 mouse model?
We have 2 Fgfr1 models in stock — including Conditional Knockout, Knockin types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Fgfr1 Mouse Model Types
A Fgfr1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Fgfr1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Fgfr1 knockin models carry a precisely inserted sequence at the Fgfr1 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Fgfr1 organized by modification type. Each URL is indexable and matches common search patterns.