Conventional / global / constitutive KO
●4 Models Available
Fgf23 Conditional Knockout, Knockin, Knockout mouse models
Browse 4 Fgf23 mouse models including conditional knockout, knockin, knockout variants from ingenious targeting laboratory. Available as Fgf23 conditional knockout mouse, Fgf23 knockin mouse, Fgf23 knockout mouse. Contact us for availability and fast turnaround.
Why model Fgf23
Fgf23, mouse ortholog of human FGF23, encodes the osteocyte and osteoblast derived endocrine regulator of phosphate homeostasis, a ligand with weak heparan sulfate binding that requires alpha-Klotho as coreceptor with FGFR1c on renal proximal tubule and parathyroid cells to suppress the sodium phosphate cotransporters NPT2a and NPT2c and to downregulate CYP27B1 while inducing CYP24A1, thereby lowering serum phosphate and active vitamin D. Bioactivity is set by furin-family cleavage at an RXXR motif that is itself blocked by GALNT3-dependent O-glycosylation, so autosomal dominant hypophosphatemic rickets arises from cleavage-resistant arginine substitutions while familial tumoral calcinosis arises from failed glycosylation or loss of function. Nulls are viable but hyperphosphatemic with ectopic calcification and short lifespan. Allele choice follows disease logic precisely: cleavage-resistant knockins model excess and reproduce XLH-like phenotypes seen with Phex loss, floxed conditionals localize the osteocyte source, and humanized knockins are required for burosumab and other antibody testing against phosphate, ALP, and rickets scoring endpoints.
What Fgf23 mouse models are available?
ingenious targeting laboratory offers 4 distinct Fgf23 (FGF23) catalog mouse models in the FGF family, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 4 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Fgf23 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Fgf23 allele types
Knockout, conditional, knockin, humanized, and related paths for Fgf23 (human FGF23). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Fgf23 catalog models
4 Fgf23 lines with QC documentation and technical support. Fgf23 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Fgf23-Flox
Conditional KnockoutKO/CKO mice
embryo cryopreservationCKO 200095 - Order
Fgf23-R176Q
Knockinpoint mutantion mice, disease model mice
embryo cryopreservationKI 200248 - Order
Fgf23-KO(2)
KnockoutKO/CKO mice
embryo cryopreservationKO 210211 - Order
Fgf23-KO
KnockoutKO/CKO mice
sperm cryopreservationKO 210111
Looking for a Fgf23 mouse model?
We have 4 Fgf23 models available — including Conditional Knockout, Knockin, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model4
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Fgf23 Mouse Model Types
A Fgf23 knockout mouse has the Fgf23 gene permanently inactivated, enabling loss of function studies. A Fgf23 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Fgf23, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Fgf23 knockin models carry a precisely inserted sequence at the Fgf23 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Fgf23 organized by modification type. Each URL is indexable and matches common search patterns.