Conventional / global / constitutive KO
●2 Models Available
Fgf8 Conditional Knockout, Knockout mouse models
Browse 2 Fgf8 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Fgf8 conditional knockout mouse, Fgf8 knockout mouse. Contact us for availability and fast turnaround.
Why model Fgf8
Fgf8, ortholog of human FGF8, encodes a secreted ligand with multiple N-terminal splice isoforms of differing potency that signals through FGFR1c, FGFR2c, FGFR3c, and FGFR4 and functions as the organizing signal at the midbrain-hindbrain isthmus, the limb apical ectodermal ridge, the pharyngeal ectoderm, and the anterior neural ridge, coupling to ERK output that sustains progenitor proliferation and positional identity. Its biology is famously dosage dependent, which is why the hypomorphic neo-insertion allelic series remains the reference tool for producing graded craniofacial, cardiac outflow, and cerebellar phenotypes that complete nulls, lethal at gastrulation, cannot deliver. Human heterozygous variants cause Kallmann syndrome and normosmic hypogonadotropic hypogonadism through GnRH neuron deficits, and holoprosencephaly-spectrum defects also occur. Conditional floxed alleles with En1-Cre, Msx2-Cre, or Nkx2-5-Cre are essential for tissue attribution, and Fgf17 and Fgf18 overlap at c-isoform receptors in isthmus and limb. Match hypomorph, conditional, or humanized allele to whether the endpoint is patterning gradient, organ morphology, or ligand pharmacology.
What Fgf8 mouse models are available?
ingenious targeting laboratory offers 2 distinct Fgf8 (FGF8) catalog mouse models in the FGF family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Fgf8 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Fgf8 allele types
Knockout, conditional, knockin, humanized, and related paths for Fgf8 (human FGF8). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Fgf8 catalog models
2 Fgf8 lines with QC documentation and technical support. Fgf8 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Selected publications from ingenious targeting laboratory
Peer reviewed work involving Fgf8 (FGF8) from ITL supported projects.
- Mouse Fgf8-Cre-LacZ lineage analysis defines the territory of the postnatal mammalian isthmus.Watson C, Shimogori T, Puelles L. (2017). J Comp Neurol525: 2782-2799
- FGF8 acts as a classic diffusible morphogen to pattern the neocortex.Toyoda R, Assimacopoulos S, Wilcoxon J, Taylor A, Feldman P, Suzuki-Hirano A, Shimogori T, Grove EA. (2010). Development137: 3439-3448
Looking for a Fgf8 mouse model?
We have 2 Fgf8 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Fgf8 Mouse Model Types
A Fgf8 knockout mouse has the Fgf8 gene permanently inactivated, enabling loss of function studies. A Fgf8 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Fgf8, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Fgf8 organized by modification type. Each URL is indexable and matches common search patterns.