Conventional / global / constitutive KO
●4 Models Available
Fgfr2 Conditional Knockout, Knockin, Knockout mouse models
Browse 4 Fgfr2 mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Fgfr2 conditional knockout mouse, Fgfr2 knockin mouse, Fgfr2 knockout mouse. Request a quote within 24 hours.
Why model Fgfr2
Fgfr2, the mouse ortholog of human FGFR2, encodes an FGF receptor whose biology is dominated by mutually exclusive splicing of exons encoding the second half of Ig domain III, producing FGFR2 IIIb in epithelium, which responds to FGF7 and FGF10 from mesenchyme, and FGFR2 IIIc in mesenchyme, which responds to epithelial FGF2, FGF8 and FGF9, establishing the reciprocal epithelial-mesenchymal loop that patterns limb, lung and craniofacial structures. Craniosynostosis alleles including S252W and P253W in Apert syndrome and cysteine substitutions in Crouzon syndrome act by broadening ligand specificity or promoting ligand-independent disulfide dimerization, while FGFR2 amplification and fusions drive gastric and intrahepatic cholangiocarcinoma. Because a conventional null is embryonic lethal from limb bud and placental failure, and because isoform-specific alleles produce entirely different phenotypes, splice-restricted alleles are the sharpest tool available. Fgfr1 and Fgfr3 compensate in skeletal contexts. Choose isoform-specific nulls for developmental patterning and conditional activating knockins for FGFR inhibitor response and resistance studies.
What Fgfr2 mouse models are available?
ingenious targeting laboratory offers 4 distinct Fgfr2 (FGFR2) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 4 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Fgfr2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Fgfr2 allele types
Knockout, conditional, knockin, humanized, and related paths for Fgfr2 (human FGFR2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Fgfr2 catalog models
4 Fgfr2 lines with QC documentation and technical support. Fgfr2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Fgfr2 mouse model?
We have 4 Fgfr2 models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model4
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Fgfr2 Mouse Model Types
A Fgfr2 knockout mouse has the Fgfr2 gene permanently inactivated, enabling loss of function studies. A Fgfr2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Fgfr2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Fgfr2 knockin models carry a precisely inserted sequence at the Fgfr2 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Fgfr2 organized by modification type. Each URL is indexable and matches common search patterns.