Conventional / global / constitutive KO
●4 Models Available
READY TO SHIP!
SPERM · EMBRYO
Fgfr2 Conditional Knockout, Knockin, Knockout mouse models
Browse 4 Fgfr2 mouse models including conditional knockout, knockin, knockout variants from ingenious targeting laboratory. Available as Fgfr2 conditional knockout mouse, Fgfr2 knockin mouse, Fgfr2 knockout mouse. Contact us for availability and fast turnaround.
Why model Fgfr2
Fgfr2, the mouse ortholog of human FGFR2, encodes an FGF receptor whose biology is dominated by mutually exclusive splicing of exons encoding the second half of Ig domain III, producing FGFR2 IIIb in epithelium, which responds to FGF7 and FGF10 from mesenchyme, and FGFR2 IIIc in mesenchyme, which responds to epithelial FGF2, FGF8 and FGF9, establishing the reciprocal epithelial-mesenchymal loop that patterns limb, lung and craniofacial structures. Craniosynostosis alleles including S252W and P253W in Apert syndrome and cysteine substitutions in Crouzon syndrome act by broadening ligand specificity or promoting ligand-independent disulfide dimerization, while FGFR2 amplification and fusions drive gastric and intrahepatic cholangiocarcinoma. Because a conventional null is embryonic lethal from limb bud and placental failure, and because isoform-specific alleles produce entirely different phenotypes, splice-restricted alleles are the sharpest tool available. Fgfr1 and Fgfr3 compensate in skeletal contexts. Choose isoform-specific nulls for developmental patterning and conditional activating knockins for FGFR inhibitor response and resistance studies.
What Fgfr2 mouse models are available?
ingenious targeting laboratory offers 4 distinct Fgfr2 (FGFR2) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 4 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Fgfr2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Fgfr2 allele types
Knockout, conditional, knockin, humanized, and related paths for Fgfr2 (human FGFR2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Fgfr2 catalog models
4 Fgfr2 lines with QC documentation and technical support. Fgfr2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Fgfr2-Flox
CKOCKO
These strains carry loxP sites flanking exon 5 of Fgfr2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Fgfr2 gene.
Sperm CryopreservedCKO 231306 - Order
Fgfr2-Flox-S252W
KIPoint Mutation
These strains carry a conditional S252W mutation of Fgfr2 gene.
Sperm CryopreservedKI 241218 - Order
Fgfr2-Flox-P253R
KIPoint Mutation
These strains carry a conditional P253R mutation of Fgfr2 gene.
Sperm CryopreservedKI 241217 - Order
Fgfr2-KO
KOKO
Exon 5 of Fgfr2 gene was deleted to generate Fgfr2 knockout mice.
F0 Embryo CryopreservedKO 225134
Looking for a Fgfr2 mouse model?
We have 4 Fgfr2 models available — including Conditional Knockout, Knockin, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Fgfr2 Mouse Model Types
A Fgfr2 knockout mouse has the Fgfr2 gene permanently inactivated, enabling loss of function studies. A Fgfr2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Fgfr2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Fgfr2 knockin models carry a precisely inserted sequence at the Fgfr2 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Fgfr2 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Fgfr2 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.