Conventional / global / constitutive KO
●4 Models Available
Fgfr3 Conditional Knockout, Knockin mouse models
Browse 4 Fgfr3 mouse models including conditional knockout, knockin variants — in stock and ready to ship from ingenious targeting laboratory. Available as Fgfr3 conditional knockout mouse, Fgfr3 knockin mouse. Request a quote within 24 hours.
Why model Fgfr3
Unlike its paralogs, Fgfr3 acts predominantly as a negative regulator of endochondral bone growth, and the mouse ortholog of human FGFR3 encodes a receptor whose activation in growth plate chondrocytes suppresses proliferation and hypertrophic differentiation through STAT1 and MAPK, which is why gain of function alleles cause dwarfism rather than overgrowth. The transmembrane G380R substitution causes achondroplasia, K650E and K650M in the activation loop cause thanatophoric dysplasia type II and SADDAN, and null mice are viable with skeletal overgrowth and inner ear defects, exactly inverting the human mutant phenotype. In cancer, S249C and Y375C drive urothelial carcinoma through ligand-independent disulfide dimerization and FGFR3-TACC3 fusions drive glioma, both targets for erdafitinib class inhibitors. Allele logic is therefore unusually clean: knockin the specific human activating codon for skeletal dysplasia and inhibitor testing, and use nulls only when asking about growth restraint. Fgfr1 and Fgfr2 do not substitute for this inhibitory function, so single-locus knockins are interpretable.
What Fgfr3 mouse models are available?
ingenious targeting laboratory offers 4 distinct Fgfr3 (FGFR3) catalog mouse models, featuring conditional knockout and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 4 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Fgfr3 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Fgfr3 allele types
Knockout, conditional, knockin, humanized, and related paths for Fgfr3 (human FGFR3). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Fgfr3 catalog models
4 Fgfr3 lines with QC documentation and technical support. Fgfr3 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Fgfr3-Flox
Conditional KnockoutKO/CKO mice, disease model mice
sperm cryopreservationCKO 2101148 - Order
Fgfr3-G374R
Knockinpoint mutantion mice
liveKI 232354 - Order
Fgfr3-N535K
Knockinpoint mutantion mice
sperm cryopreservationKI 232380 - Order
Fgfr3-P244R
Knockinpoint mutantion mice, disease model mice
sperm cryopreservationKI 240342
Looking for a Fgfr3 mouse model?
We have 4 Fgfr3 models in stock — including Conditional Knockout, Knockin types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model4
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Fgfr3 Mouse Model Types
A Fgfr3 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Fgfr3, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Fgfr3 knockin models carry a precisely inserted sequence at the Fgfr3 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Fgfr3 organized by modification type. Each URL is indexable and matches common search patterns.