Conventional / global / constitutive KO
●3 Models Available
Fgfr4 Conditional Knockout, Knockout mouse models
Browse 3 Fgfr4 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Fgfr4 conditional knockout mouse, Fgfr4 knockout mouse. Contact us for availability and fast turnaround.
Why model Fgfr4
Fgfr4, mouse ortholog of human FGFR4, encodes the FGF receptor most distinguished by its endocrine ligand relationship, forming a complex with beta-klotho to serve as the hepatic receptor for FGF19 (mouse Fgf15), which represses CYP7A1 transcription and thereby closes the bile acid feedback loop from ileum to liver. Unlike other family members, FGFR4 undergoes limited receptor internalization and lacks IIIb and IIIc alternative splicing, simplifying allele design. The germline G388R polymorphism enhances STAT3 signaling and associates with cancer progression, FGF19 amplification with FGFR4 dependency defines a hepatocellular carcinoma subset targeted by covalent inhibitors such as fisogatinib and roblitinib, and FGFR4 sustains rhabdomyosarcoma. Null mice are viable with elevated bile acid pool and depleted gallbladder, and only show skeletal phenotypes when combined with Fgfr3 alleles, indicating real but limited redundancy. Use conditional hepatocyte nulls for bile acid and hepatocarcinogenesis questions, and humanized kinase domain knockins when covalent inhibitor cysteine reactivity must translate.
What Fgfr4 mouse models are available?
ingenious targeting laboratory offers 3 distinct Fgfr4 (FGFR4) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Fgfr4 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Fgfr4 allele types
Knockout, conditional, knockin, humanized, and related paths for Fgfr4 (human FGFR4). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Fgfr4 catalog models
3 Fgfr4 lines with QC documentation and technical support. Fgfr4 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Fgfr4 mouse model?
We have 3 Fgfr4 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Fgfr4 Mouse Model Types
A Fgfr4 knockout mouse has the Fgfr4 gene permanently inactivated, enabling loss of function studies. A Fgfr4 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Fgfr4, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Fgfr4 organized by modification type. Each URL is indexable and matches common search patterns.